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1. Progesterone also has a role in skin elasticity and bone strength, in respiration, in nerve tissue and in female sexuality, and the presence of progesterone receptors in certain muscle and fat tissue may hint at a role in sexually dimorphic proportions of those.

2. During pregnancy, progesterone is said to decrease irritability.

3. During pregnancy, progesterone helps to suppress immune responses of the mother to fetal antigens, which prevents rejection of the fetus.

4. Progesterone raises epidermal growth factor-1 (EGF-1) levels, a factor often used to induce proliferation, and used to sustain cultures, of stem cells.

5. Progesterone increases core temperature (thermogenic function) during ovulation.

6. Progesterone reduces spasm and relaxes smooth muscle. Bronchi are widened and mucus regulated. (PRs are widely present in submucosal tissue.)

7. Progesterone acts as an antiinflammatory agent and regulates the immune response.

8. Progesterone reduces gall-bladder activity.

9. Progesterone normalizes blood clotting and vascular tone, zinc and copper levels, cell oxygen levels, and use of fat stores for energy.

10. Progesterone may affect gum health, increasing risk of gingivitis (gum inflammation).

11. Progesterone appears to prevent endometrial cancer (involving the uterine lining) by regulating the effects of estrogen.

12. Progesterone plays an important role in the signaling of insulin release and pancreatic function, and may affect the susceptibility to diabetes or gestational diabetes.