Brand: NJBNSTEROID
Model: 2627-69-2
Price: CNY 1 / g
Min. Order: 5g g
AICAR
2627-69-2
SARM
SARM Steroids AICAR CAS 2627-69-2 Nucleoside Analogue Adenosine-regulating Agents


Basic Info:

Name AICAR
CAS 2627-69-2
MF C9H14N4O5
MW 258.23
EINECS 220-097-5
Product Categories Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Cardiovascular
Chemical Properties white or off-white solid
Assay 99%
                            
Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown . Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

What is AICAR ?

SARM AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK) , a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes . In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Application:

Exercise improves insulin sensitivity.
a single dose of AICAR leads to an apparent enhancement in whole-body, muscle, and liver insulin action in HF rats that extends beyond the expected time of AMPK activation. Whether altered tissue lipid metabolism mediates AICAR effects on insulin action remains to be determined. the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes​

Function:

SARM AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown . Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

Biological Activity:

Cell-permeable , allosteric activator of AMP-activated protein kinase (AMPK) . Augments proliferation , differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

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