Brand: NJBNSTEROID
Model: 50-02-2
Price: USD 1 / g
Min. Order: 5g g
Dexamethasone
50-02-2
Anti-inflammatory Agent
CAS 50-02-2 Active Pharmaceutical Ingredients Dexamethasone 98% Anti-inflammatory Agent


Product Detials:

Product name Dexamethasone
Other name 16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2
CAS register number 50-02-2
EINECS 200-003-9
Molecular formula C22H29FO5
Appearance White crystalline powder
Molecular weight 392.46
Manufacturer NJBN STEROID
Molecular structure
Melting point 262-264°C
Assay 98%
Usage A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth , and differentiation . Inhibits the induction of nitric oxide synthase

Product Description:

Active Pharmaceutical Ingredients Dexamethasone is used to treat many inflammatory and autoimmune conditions , such as rheumatoid arthritis and bronchospasm . Idiopathic thrombocytopenic purpura , a decrease in numbers of platelets due to an immune problem , responds to 40 mg daily for four days ; it may be administered in 14-day cycles . It is unclear whether dexamethasone in this condition is significantly better than other glucocorticoids.
It is also given in small amounts before and/or after some forms of dental surgery , such as the extraction of the wisdom teeth , an operation which often leaves the patient with puffy, swollen cheeks.

COA:

Product name Dexamethasone
Appearance White crystalline powder
Specific optical rotation Between+72°and +80° +76.4°
Chromatographic purity Any individual impurity not more than 1.0%
Total impurities not more than 2.0% 0.46%
1.13%
Loss on drying Not more than 0.5% 0.11%
Residue on ignition Not more than 0.2% 0.06%
Residual solvents Methanol≤3000ppm
Methylene Chloride≤600ppm
Chloroform≤60ppm
Tetrahydrofuran≤720ppm 364ppm
Not detect out
Not detect out
Not detect out
Assay Between 97.0% and 102.0% 98.1%
Micronixation 90% not more than 10 microns 90% not more than 10
aicrons

Active Pharmaceutical Ingredients Applications:

It is injected into the heel when treating plantar fasciitis, sometimes in conjunction with triamcinolone acetonide.
It is useful to counteract allergic anaphylactic shock , if given in high doses.
It is present in certain eye drops – particularly after eye surgery – and as a nasal spray (trade name Dexacort) , and certain ear drops (Sofradex, when combined with an antibiotic and an antifungal) . Dexamethasone intravitreal steroid implants (trade name Ozurdex) have been approved by the FDA to treat ocular conditions such as diabetic macular edema , central retinal vein occlusion, and uveitis.
Dexamethasone is used in transvenous screw-in cardiac pacing leads to minimize the inflammatory response of the myocardium . The steroid is released into the myocardium as soon as the screw is extended and can play a significant role in minimizing the acute pacing threshold due to the reduction of inflammatory response . The typical quantity present in a lead tip is less than 1.0 mg.
Dexamethasone is often administered before antibiotics in cases of bacterial meningitis . It then acts to reduce the inflammatory response of the body to the bacteria killed by the antibiotics (bacterial death releases proinflammatory mediators that can cause a response which is harmful to the patient), thus improving prognosis and outcome.

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