Brand: Sildenafil
Model: 171599-83-0
Price: CNY 405 / kg
Sildenafil
penile erectile dysfunction
cardiac parameters
This product is the treatment of penile erectile dysfunction (ED) oral medication. It is citrate of sildenafil, a selective inhibitor of type 5 phosphodiesterase (PDE5) specific for cyclic guanosine monophosphate (cGMP). Mechanisms: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO activating guanylate cyclase results in elevated levels of cyclic guanosine monophosphate (cGMP), smooth muscle relaxation in the corpus cavernosum, and blood filling.
(Sildenafil, Viagra, Viagra) is a highly selective phosphodiesterase 5 (PDE5) inhibitor, PDE5 is highly expressed in the corpus cavernosum, and the effect of sildenafil on penile erection is: While in other tissues (including platelets, blood vessels and visceral smooth muscle, skeletal muscle), expression is low. Sildenafil causes selective erectile response to sexual stimulation by selective inhibition of PDE5, enhancement of nitric oxide (NO) -cGMP pathway, increased cGMP levels resulting in smooth muscle relaxation of the penile corpus cavernosum. Erectile response is generally enhanced with the increase in sildenafil and plasma concentrations. Experiments show that the efficacy of sustainable to 4 hours, but the reaction is less than 2 hours. Sildenafil response to myocardium: PDE5 is absent in normal or diseased cardiac conduction tissue, cardiomyocytes, endothelial cells, lymphoid tissue, so that sildenafil (PDE5 inhibitor) has no positive muscle strength, Directly affect the myocardial systolic function.
Effects of sildenafil on cardiac parameters: Normal male volunteers were orally administered 100 mg of sildenafil, with no clinically significant electrocardiogram changes. 8 patients with stable ischemic heart disease under the monitoring of Swan-Ganz catheter, 4 times intravenous injection of a total of 40mg of sildenafil, the results: resting state, the patient's contractility and diastolic blood pressure than baseline Respectively, down 7% and 10%. Resting right atrium, pulmonary artery pressure, pulmonary artery wedge pressure and cardiac output were down by 28%, 28%, 20% and 7%, respectively. Although this intravenous dose was 2 to 5 times higher than the mean peak plasma dose of sildenafil 100 mg for healthy male volunteers, the above hemodynamic response was still present.
In the sexual stimulation, the corpus cavernosum non-gonadotropin can non-cholinergic neurons and vascular endothelial cells nitric oxide synthase catalyzes L-arginine synthesis of nitric oxide, which activates guanylate cyclase to ring Guanosine synthesis increased, and then cause penile corpus cavernosum smooth muscle and small artery smooth muscle relaxation, blood into the penis cavernous sinus, so that penile erection. At the same time, cyclic guanosine monophosphate is hydrolyzed by phosphodiesterase.
Main Ingredients and Chemical Name: 1- [4-Ethoxy-3- [5- (6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4 , 3d] pyrimidine)] benzenesulfonyl] -4-methylpiperazine citrate This product is a blue rhombic film, remove the film after the white powder.
Role: erectile dysfunction