Fludrocortisone
Fludrocortisone (also called 9α-Flouocortisol) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency.
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Uses
It has been used in the treatment of cerebral salt wasting.
It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia.
It is the first line of treatment for orthostatic intolerance as well.
It is also a confirmation test for diagnosing Conns Syndrome (Aldosterone producing-Adrenal adenoma), the fludrocortisone suppression test. Loading the patient with fludrocortisone would suppress serum aldosterone level in a normal patient, whereas the level will not be altered in a Conns patient