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Local Anesthetic Drugs Bupivacaine Hydrochloride Cas 14252-80-3 99%

Detailed Selling Lead Description
Brand: NJBNSTEROID
Model: 14252-80-3
Price: USD 1 / g
Min. Order: 5g g
Bupivacaine Hydrochloride
14252-80-3
Local Anesthetic
Local Anesthetic Drugs Bupivacaine Hydrochloride CAS 14252-80-3 99%


1 . Basic info:

Product Name bupivacaine hydrochloride
Synonyms 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide ; 1-Butyl-N-(2,6-
dimethylphenyl)-2-piperidinecarboxamide hydrochloride ; Bupivocoine HCl;
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1);
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride;
Bupivacaine Hcl; 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-,
monohydrochloride; 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride (6CI); Marcaina;
BUPIVACAINE HYDROCHLORIDE ANHYDROUS
Molecular Formula C18H31ClN2O2
Molecular Weight 342.9039
InChI InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)
9-8-
10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H
CAS Registry Number 14252-80-3;18010-40-7
EINECS 241-917-8
Molecular Structure
Boiling point 423.4°C at 760 mmHg
Flash point 209.9°C
Vapour Pressure 2.24E-07mmHg at 25°C
                        
Usage Sodium channel blocker , local anesthetic

DESCRIPTION:

Bupivacaine Hydrochloride is 2-Piperidinecarboxamide , 1-butyl-N-(2,6-dimethylphenyl)- , monohydrochloride , monohydrate , a white crystalline powder that is freely soluble in 95 percent ethanol , soluble in water , and slightly soluble in chloroform or acetone. It has the following structural formula :
       
Bupivacaine Hydrochloride is available in sterile isotonic solutions with and without epinephrine (as bitartrate) 1 : 200 ,000 for injection via local infiltration, peripheral nerve block , and caudal and lumbar epidural blocks . Solutions of Bupivacaine Hydrochloride may be autoclaved if they do not contain epinephrine . Solutions are clear and colorless.
Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics . It is a homologue of mepivacaine and is chemically related to lidocaine. All three of these anesthetics contain an amide linkage between the aromatic nucleus and the amino , or piperidine group . They differ in this respect from the procaine-type local anesthetics , which have an ester linkage.

CLINICAL PHARMACOLOGY:

Local anesthetics block the generation and the conduction of nerve impulses , presumably by increasing the threshold for electrical excitation in the nerve , by slowing the propagation of the nerve impulse , and by reducing the rate of rise of the action potential . In general, the progression of anesthesia is related to the diameter , myelination , and conduction velocity of affected nerve fibers . Clinically, the order of loss of nerve function is as follows : (1) pain , (2) temperature , (3) touch , (4) proprioception , and (5) skeletal muscle tone.

INDICATIONS AND USAGE:

Bupivacaine Hydrochloride is indicated for the production of local or regional anesthesia or analgesia for surgery , dental and oral surgery procedures , diagnostic and therapeutic procedures , and for obstetrical procedures.

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